Research Article
Open Access
Prediction of Antihypertensive Activity of Substituted Piperidines as Highly Potent Renin Inhibitors Due to induced Fit Adaptation of the Active Fit Site
Shailja Sachan1*, Amitabh Tripathi2, Pradeep Chandra Shukla3
1Department of Chemistry, Govt. MSG College,Rewa, M.P. India.
2Department Of Chemistry, Awadhesh Pratap Singh University, Rewa, M.P. India.
3Department Of Chemistry, Y.P.S. College, Sirmour, Rewa, M.P., India.
Shailja Sachan K et al /Int.J. Chemical Concepts. 2015,1(1),pp 19-25.
Abstract
We have studied a series of substituted Piperidines for predicting their Antihypertensive
Activity of Renin inhibition on QSAR models.We have chosen certain descriptors viz. ZM1, Pol,
MSD, CSI, X0, J_A,Wi_D, Wi_H2 and Hy in our study and found that molecular descriptors
Hydrophilic factor, Eccentric Connectivity index, zero order connectivity index and Wiener-like index
from topological distance matrix are very closely related with antihypertensive activity of these
compounds.
Keywords
Antihypertensive, Piperidines, Renin Inhibitors, QSAR Study.